Low-Molecular-Weight Heparin Successfully Used to Treat a Nephrotic Patient Complicated by Superior Mesenteric Vein Thrombosis and Portal Vein Thrombosis

Objectives: To report the success of treatment with lowmolecular-weight heparins (LMWHs) in a case of nephrotic syndrome complicated by mesenteric vein thrombosis (MVT) and portal vein thrombosis (PVT). Clinical Presentation and Intervention: A 53-year-old man with nephrotic syndrome developed persistent mild abdominal pain for 3 days. Hepatic-portal venous system thrombosis of nephrotic syndrome was suspected due to new-onset superficial vein engorgement of the abdomen without liver cirrhosis. Abdominal computed tomography revealed MVT concomitant with PVT. He was successfully treated with LMWH without thrombolytic therapy. After discharge on day 9, he received continuous anticoagulation by LWMH on an outpatient basis at the nephrology clinic. Venous thromboembolic events or proteinuria did not recur within the 6-month follow-up. Conclusion: This report showed a case of MVT concomitant with PVT, a critical complication of nephrotic syndrome that was Received: February 8, 2010 Accepted: June 6, 2010 Chih-Hsiung Lee Division of Nephrology, Chang Gung Memorial Hospital, Kaohsiung Medical Center 123 Ta-Pei Road Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan (ROC) Tel. +886 7 7317 123 ext. 8306, Fax +886 7 7322 402, E-Mail m92chung @ yahoo.com.tw © 2011 S. Karger AG, Basel 1011–7571/11/0202–0196$38.00/0 Accessible online at: www.karger.com/mpp D ow nl oa de d by : 54 .7 0. 40 .1 1 11 /1 9/ 20 17 1 2: 28 :2 6 P M